CDC developed the guideline using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework, and recommendations are made on the basis of a systematic review of the scientific evidence while considering benefits and harms, values and preferences, and resource allocation. The guideline addresses 1) when to initiate or continue opioids for chronic pain 2) opioid selection, dosage, duration, follow-up, and discontinuation and 3) assessing risk and addressing harms of opioid use. If you are at high risk for an overdose, ask your health care provider about whether you need a prescription for naloxone.This guideline provides recommendations for primary care clinicians who are prescribing opioids for chronic pain outside of active cancer treatment, palliative care, and end-of-life care. If you take an opioid, it is also important to teach your family and friends how to respond to an overdose. Besides keeping children safe, it also prevents someone who lives with you or visits your house from stealing your medicines.
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